2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Z0081
    2S,4R-Sacubitril
    2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
    2S,4R-Sacubitril
  • HY-133771AS
    Nordoxepin-d3 hydrochloride
    		≥99.0%
    Nordoxepin-d3 (hydrochloride) is the deuterium labeled Nordoxepin hydrochloride. Nordoxepin hydrochloride is an active metabolite of Doxepin hydrochloride (HY-B0725), which is an orally active tricyclic antidepressant[1].
    Nordoxepin-d<sub>3</sub> hydrochloride
  • HY-116787
    5-Hydroxythiabendazole
    5-Hydroxythiabendazole (5-OHTBZ) is a biomarker of Thiabendazole (HY-B0263) exposure.
    5-Hydroxythiabendazole
  • HY-143992S
    Maytansinoid DM4 impurity 2-d6
    Maytansinoid DM4 impurity 2-d6 is the deuterium labeled Maytansinoid DM4 impurity 2[1].
    Maytansinoid DM4 impurity 2-d<sub>6</sub>
  • HY-131263
    Hydroxychloroquine Impurity F
    Hydroxychloroquine Impurity F is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.
    Hydroxychloroquine Impurity F
  • HY-145000
    N-Desalkyludenafil
    N-Desalkyludenafil is a metabolite of Udenafil. Udenafil is a PDE5 inhibitor used for the research of the erectile dysfunction.
    N-Desalkyludenafil
  • HY-114750S
    Mebendazole-amine-13C6
    Mebendazole-amine-13C6 is the 13C6 labeled Mebendazole-amine. Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent.
    Mebendazole-amine-<sup>13</sup>C<sub>6</sub>
  • HY-143986S1
    DM50 impurity 1-d9-1
    DM50 impurity 1-d9-1 is the deuterium labeled DM50 impurity 1[1].
    DM50 impurity 1-d<sub>9</sub>-1
  • HY-G0018R
    Norgestimate metabolite Norelgestromin (Standard)
    Norgestimate metabolite Norelgestromin (Standard) is the analytical standard of Norgestimate metabolite Norelgestromin. This product is intended for research and analytical applications.
    Norgestimate metabolite Norelgestromin (Standard)
  • HY-141621
    ACT-606559
    ACT-606559, a new chemical entity with antimalarial activity, is a metabolite of ACT451840. ACT-606559 can be used for the research of malarial.
    ACT-606559
  • HY-144142S
    Orphenadrine impurity 6-d3 hydrochloride
    Orphenadrine impurity 6-d3 (hydrochloride) is the deuterium labeled Orphenadrine impurity 6 hydrochloride[1].
    Orphenadrine impurity 6-d<sub>3</sub> hydrochloride
  • HY-131254
    (S)-O-Desmethyl Venlafaxine N-Oxide
    (S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
    (S)-O-Desmethyl Venlafaxine N-Oxide
  • HY-122423
    Desethylamiodarone
    Desethylamiodarone (N-Deethylamiodarone) is the major metabolite of antiarrhythmic compound Amiodarone (HY-14187). Desethylamiodarone has antiarrhythmic activity. Desethylamiodaron also induces cancer cell apoptosis.
    Desethylamiodarone
  • HY-135404
    Anhydrosimvastatin
    Anhydrosimvastatin (Impurity C) is an impurity of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase.
    Anhydrosimvastatin
  • HY-N11485
    (25R)-12α-Hydroxyspirost-4-en-3-one
    (25R)-12α-Hydroxyspirost-4-en-3-one is a minor metabolite produced by the action of Nocardia globerula on Hecogenin (HY-N1422).
    (25R)-12α-Hydroxyspirost-4-en-3-one
  • HY-133772
    Venetoclax N-oxide
    Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM.
    Venetoclax N-oxide
  • HY-114917
    Aldophosphamide
    Aldophosphamide (NSC 254) is a cyclophosphamide metabolite. Aldophosphamide is cleaved intracellularly to phosphoramide mustard, an active metabolite with direct cytotoxicity, and acrolein. Aldophosphamide has potential for cancer research.
    Aldophosphamide
  • HY-135386
    5β-​Dutasteride
    5β-Dutasteride is the S configuration of Dutasteride. 5β-Dutasteride is a potent inhibitor of both 5 alpha-reductase isozymes.
    5β-​Dutasteride
  • HY-116462
    ONO-EI-601
    ONO-EI-601 is the major metabolite of human neutrophil elastase inhibitor ONO-5046. ONO-5046 has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
    ONO-EI-601
  • HY-143960S
    Givinostat impurity 1-d10 hydrochloride
    Givinostat impurity 1-d10 (hydrochloride) is the deuterium labeled Givinostat impurity 1 hydrochloride[1].
    Givinostat impurity 1-d<sub>10</sub> hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity